Immunogenical Study of Chimeric Recombinant Intimin-Tir of Escherichia coli O157:H7 in Mice
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چکیده
منابع مشابه
Immunogenical Study of Chimeric Recombinant Intimin-Tir of Escherichia coli O157:H7 in Mice
Background: Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis. The most important reservoirs of this bacterium are domestic ruminant, particularly the cattle. Although it has low prevalence, the severity of consequent diseases of this bacterium brings concerns to develop effective vaccines. This bacterium is able to produce attaching-effacing (A/E) lesions in intestin...
متن کاملimmunogenical study of chimeric recombinant intimin-tir of escherichia coli o157:h7 in mice
results the results showed that the chimeric recombinant protein induced strong humoral response as well as protection against live oral challenges using e. coli o157:h7. conclusions the rit could reduce bacterial shedding effectively. objectives the eae gene encoded intimin protein which is essential for colonization of the mucosa and a/e lesions formation by docking to the tir. materials and ...
متن کاملInteraction of the enteropathogenic Escherichia coli protein, translocated intimin receptor (Tir), with focal adhesion proteins.
When enteropathogenic Escherichia coli (EPEC) attach and infect host cells, they induce a cytoskeletal rearrangement and the formation of cytoplasmic columns of actin filaments called pedestals. The attached EPEC and pedestals move over the surface of the host cell in an actin-dependent reaction [Sanger et al., 1996: Cell Motil Cytoskeleton 34:279-287]. The discovery that EPEC inserts the prote...
متن کاملChitosan-Based Intranasal Vaccine against Escherichia coli O157:H7
Background: Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is an infectious zoonotic pathogen causing human infections. These infections, in some cases, can lead to hemolytic uremic syndrome and its life-threatening complications and even death worldwide. The first intimate bacterial adhesion, intimin (I), with its own receptor translocated intimin receptor (Tir) and E. coli secreted protein...
متن کاملExpression, purification, and immunization of a chimeric protein containing immunogenic regions of flagellin and intimin proteins against E. coli O157: H7
Introduction: Enterohemorrhagic Escherichia coli (EHEC) and serotype O157: H7 is one of the most important diseases causing diarrhea. Shiga-like toxin secreted by the bacteria destroys epithelial cells and, in acute cases, causes hemolytic uremic syndrome (HUS). Antibiotic therapy is not effective against this pathogen, because it increases the production of Shiga toxin. Designing chimeric immu...
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ژورنال
عنوان ژورنال: Archives of Clinical Infectious Diseases
سال: 2012
ISSN: 2345-2641
DOI: 10.5812/archcid.14068